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Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures

J Am Chem Soc. 2021-12; 
Denise Liano, Souroprobho Chowdhury, Marco Di Antonio
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Proteins, Expression, Isolation and Analysis Proteins were purified from supernatants with affinity Ni-NTA (Qiagen) or protein-A (GenScript) chromatography before further purification by SEC on HiLoad 16/600 Superdex 200 (GE Healthcare) or Superdex 200 10/300 GL (GE Healthcare) columns. Get A Quote

摘要

Guanine-rich DNA can fold into secondary structures known as G-quadruplexes (G4s). G4s can form from a single DNA strand (intramolecular) or from multiple DNA strands (intermolecular), but studies on their biological functions have been often limited to intramolecular G4s, owing to the low probability of intermolecular G4s to form within genomic DNA. Herein, we report the first example of an endogenous protein, Cockayne Syndrome B (CSB), that can bind selectively with picomolar affinity toward intermolecular G4s formed within rDNA while displaying negligible binding toward intramolecular structures. We observed that CSB can selectively resolve intermolecular over intramolecular G4s, demonstrating that its selec... More

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