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BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and

Vaccines (Basel). 2022-05; 
Jorge A Soto, Fabián E Díaz, Angello Retamal-Díaz, Nicolás M S Gálvez, Felipe Melo-González, Alejandro Pi?a-Iturbe, Mario A Ramírez, Karen Bohmwald, Pablo A González, Susan M Bueno, Alexis M Kalergis
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Proteins, Expression, Isolation and Analysis … the Nucleoprotein of SARS-CoV-2 (N-SARS-CoV-2), the sequence of this gene was synthesized by GenScript. Then, the DNA coding sequence of the N-SARS-CoV-2 protein was … Get A Quote

摘要

Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine mainly administered to newborns and used for over 100 years to prevent the disease caused by (). This vaccine can induce immune response polarization towards a Th1 profile, which is desired for counteracting , other mycobacteria, and unrelated intracellular pathogens. The vaccine BCG has been used as a vector to express recombinant proteins and has been shown to protect against several diseases, particularly respiratory viruses. BCG was used to develop recombinant vaccines expressing either the Nucleoprotein from SARS-CoV-2 or . Mice were immunized with these vaccines with the aim of evaluating the safety and immunogenicity parameters. Immunization... More

關鍵詞

Andes orthohantavirus, SARS-CoV-2, immune response, recombinant BCG, trained immunity
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