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Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence

Pharm Biol. 2022-12; 
Chuanyuan Ji, Cong Wei, Mengnan Li, Shuang Shen, Shixiong Zhang, Yunlong Hou, Yiling Wu
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Proteins, Expression, Isolation and Analysis … In each well, 40 μg of protein were loaded and separated by electrophoresis at 120 V in precast 4–20% polyacrylamide gels (GenScript Biotech, Nanjing, China) and transferred to a … Get A Quote

摘要

unassigned: Bazi Bushen capsule (BZBS) has anti-ageing properties and is effective in enhancing memory. unassigned: To find evidence supporting the mechanisms and biomarkers by which BZBS functions. unassigned: Male C57BL/6J mice were randomly divided into five groups: normal, ageing, β-nicotinamide mononucleotide capsule (NMN), BZBS low-dose (LD-BZ) and BZBS high-dose (HD-BZ). The last four groups were subcutaneously injected with d-galactose (d-gal, 100?mg/kg/d) to induce the ageing process. At the same time, the LD-BZ, HD-BZ and NMN groups were intragastrically injected with BZBS (1 and 2?g/kg/d) and NMN (100?mg/kg/d) for treatment, respectively. After 60?days, the changes in overall ageing status, b... More

關鍵詞

Synaptic plasticity, ageing, microglia polarization, senescence-associated secretory phenotype, traditional Chinese medicine
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