国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding.

Molecules. 2019-04; 
ManikowskiDominique,JakobsPetra,JboorHamodah,Grob
Products/Services Used Details Operation
Recombinant Proteins Glycan microarray analysis was conducted by Glycan Therapeutics (Raleigh, NC, USA) with purified recombinant murine Shh (GenScript, Piscataway, NJ, USA). Get A Quote

摘要

Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc). These receiving cells respond by producing other soluble factors that promote cancer cell growth, generating a positive feedback loop. To interfere with reinforced Shh signaling, we examined the potential of defined heparin and heparan sulfate (HS) polysaccharides to block Shh solubilization and Ptc receptor binding. We confirm in vitro and in vivo that proteolytic cleavage of the N-terminal Cardin-Weintraub (CW) amino acid motif is a prerequisite for Shh solubilization and function. Consistent with the estab... More

關鍵詞

hedgehog,heparan sulfate,hep
              主站蜘蛛池模板: 汉沽区| 合川市| 互助| 轮台县| 汽车| 中江县| 西乌珠穆沁旗| 廊坊市| 炉霍县| 长宁县| 东乡族自治县| 南靖县| 阜城县| 肃北| 宝坻区| 贡嘎县| 土默特右旗| 长宁区| 航空| 汝南县| 曲沃县| 河津市| 阜阳市| 泰顺县| 元阳县| 凤山县| 南部县| 达尔| 鹿邑县| 林西县| 连山| 方正县| 开鲁县| 扶余县| 洞头县| 家居| 崇左市| 宁德市| 三台县| 吴忠市| 石渠县|