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Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding.

Molecules. 2019-04; 
ManikowskiDominique,JakobsPetra,JboorHamodah,Grob
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Recombinant Proteins Glycan microarray analysis was conducted by Glycan Therapeutics (Raleigh, NC, USA) with purified recombinant murine Shh (GenScript, Piscataway, NJ, USA). Get A Quote

摘要

Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc). These receiving cells respond by producing other soluble factors that promote cancer cell growth, generating a positive feedback loop. To interfere with reinforced Shh signaling, we examined the potential of defined heparin and heparan sulfate (HS) polysaccharides to block Shh solubilization and Ptc receptor binding. We confirm in vitro and in vivo that proteolytic cleavage of the N-terminal Cardin-Weintraub (CW) amino acid motif is a prerequisite for Shh solubilization and function. Consistent with the estab... More

關鍵詞

hedgehog,heparan sulfate,hep
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